The Stress in Crohn’s study is a Helmsley Foundation funded multi-site prospective cohort study of patients with established Crohn’s disease. For this project, 4YouandMe has partnered with clinicians at Oxford University in the United Kingdom and Mount Sinai School of Medicine in the United States comprising the two clinical sites where patients will be enrolled starting in the fall, 2019. The aim of this project is to explore the feasibility of following stress using wearable devices to predict the risk of upcoming symptom changes. We will try to achieve this through close and continuous physiological and behavioral measurements using a study companion app installed on the participant's own phone, which will track both passive sensor measures and active tasks such as a step test to measure fatigue. Additionally, a smart wristwatch, a smart scale, and smart ring will be given to participants. These devices allow us to collect real time signals of stress almost continually and to couple this data to patient reported symptoms of their Crohn’s disease and levels of stress. Our goal through this work is to eventually help people with Crohn’s disease manage their own symptoms between clinician visits. Clues identified from this clinical study could provide an “early detection system” to enable each patient to adapt aspects of their eating, medication, and behavior including exposure to modifiable stress, to prevent negative clinical changes in their condition.