The Central Nervous System (CNS) tumor detection study is a Mark Foundation funded prospective cohort study launching in the fall 2019. 4YouandMe has partnered with clinicians from the National Institutes of Neurological Diseases and Stroke and the Children’s National Hospital in Washington, DC where adult and pediatric patients with high grade primary brain tumors, including glioblastoma (GBM, primarily adult population) and diffuse intrinsic pontine glioma (DIPG, primarily pediatric population) will be recruited. These patient populations represent devastating disease processes with high symptomatic burden and near universal progression and recurrence. The aim of this study is to assess the feasibility to detect and track symptom transitions using connected digital tools to develop a sensor map of symptom progression. This study will track 100 patients using wearable devices before their surgery/radiation therapy and will follow them during the postoperative period for one year. We plan to collect semi-continuous passive and active measurements using smartphone applications to collect and transmit data, alongside the smart ring and smart wristwatch. We plan to retrospectively analyze relative changes of multi-modal data streams among those who did and did not demonstrate new tumor growth. The goal of this project is to identify digital biomarkers that could eventually help provide methods for screening individuals as an early detection system.